Washington has grown increasingly frustrated with the government of South Sudan's President Salva Kiir
The six would face a global travel ban and assets freeze if the draft resolution is adopted at a meeting scheduled for Thursday.
The council will meet Tuesday to discuss the US sanctions proposal that comes as Washington has grown increasingly frustrated with President Salva Kiir's government.
South Sudan won independence from Sudan in 2011, with critical backing from the United States, which remains Juba's biggest aid donor.
Countless efforts have failed to bring peace to a country now in its fifth year of a war where targeted ethnic killings, gang rapes and other atrocities have occurred.
The proposed sanctions blacklist would target Defense Minister Kuol Manyang Juk for violating the latest ceasefire signed by the government last year and for leading attacks on the northeastern town of Pagak that was captured from rebel forces in 2017.
Also listed is cabinet minister Martin Elia Lomuro for threatening the press, obstructing humanitarian aid and impeding the work of the UN peacekeeping mission in South Sudan.
Information Minister Michael Makuei is cited for his role in planning an attack in 2014 on a United Nations compound in Bor and overseeing a campaign to suppress the media.
Former military chief Paul Malong faces possible sanctions for ordering government forces to attack civilians, schools and hospitals and deputy army chief of staff Malek Reuben for overseeing an offensive in 2015.
The proposed sanctions list also includes Koang Rambang Chol for leading attacks in northern Bieh state and ordering his forces to impede the work of aid workers, according to the draft.
The draft resolution would also extend the sanctions imposed on South Sudan for another year and renew the mandate of a UN panel of experts.
There are currently six names of senior generals and rebel commanders on the UN sanctions list.
South Sudan descended into civil war in late 2013 when Kiir accused former vice president Riek Machar of plotting a coup.
In the years since, millions have been uprooted, triggering a regional refugee crisis, and millions more have been pushed to the brink of starvation, while tens of thousands have been killed.
The United States has repeatedly threatened to impose an arms embargo and sanctions against those blocking efforts to end the war.
In 2016, Washington failed to win enough votes at the Security Council for the arms embargo and targeted sanctions.
Ethiopia is leading a regional peace effort, hosting talks between the government and rebel groups but there has been no breakthrough.
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