The food crisis in the world's youngest country is one of the key issues being discussed at this week's World Economic Forum on Africa, which has brought together the continent's business and political elite in Durban.
Saira Khan, the chief executive of the charity Stop Hunger Now Southern Africa, warned that a chaotic international response to the situation in South Sudan was threatening the lives of millions.
"It's pretty gloomy. We're seeing a lot of confusion amongst the NGOs and governments in terms of what needs to be done," she said.
"It's a difficult time for that region -- and if we don't do anything we're going to have six million people dead at the end of this year because of famine."
In February, South Sudan and the United Nations formally declared a famine in some parts of the northern Greater Unity region affecting 100,000 people, a disaster UN officials said was "man-made" and could have been averted.
More than 1.9 million South Sudanese are internally displaced and at least 1.7 million have fled to safety across the country's borders so far -- including a total of 830,000 to neighbouring Uganda
After gaining independence from Sudan in 2011, the country descended into civil war in December 2013 when a power struggle erupted between President Salva Kiir and his former deputy Riek Machar. Tens of thousands of people died and more than 3.5 million have been displaced.
"The real instability in the area with the war and migrants just going and settling where they can has contributed to this and put enormous pressure on Somalia, Sudan, Ethiopia, Kenya, Uganda," Khan said.
Oxfam International's executive director Winnie Byanyima told AFP that a huge funding shortfall for relief efforts was threatening lives.
- Go hungry or 'be raped' -
Oxfam says that the UN will need $4.4 billion for its famine relief operations by July to avoid widespread loss of life in South Sudan -- but just 26 percent of that has been raised so far.
"The need is huge, the gap is huge," Byanyima said. "It needs to be filled urgently. When people die in a famine it's a sign of failure because you can prevent it if you act early enough."
The food crisis in South Sudan is one of the key issues being discussed at this week's World Economic Forum on Africa in Durban, which has brought together the continent's business and political elite
More than 1.9 million people are internally displaced and at least 1.7 million have fled to safety across the country's borders so far. A total of 830,000 South Sudanese refugees are in neighbouring Uganda and the UN expects this figure will reach more than a million by mid-year.
"I visited places where people are trapped in what are called 'protection of civilian' camps. The women there face a choice between hunger or stepping out and being raped while looking for food," Byanyima said.
Elsewhere in Africa, Byanyima warned that Nigeria could face its own famine crisis.
"I have just been to northeast Nigeria, a region that has been devastated by Boko Haram," she said. "There are 47,000 people living there in famine-like conditions. Another five million could experience famine in the next few months".
The World Food Programme says that 4.7 million people across three areas of northeast Nigeria are already facing acute hunger while the Red Cross warns that five children are dying daily of starvation.
Byanyima called for the United Nations to be overhauled to face the challenges in South Sudan.
"Today it is so dysfunctional and unable to get the Security Council to bear pressure on leaders who are behaving irresponsibly such as in South Sudan," she said.
UNESCO special envoy Forest Whitaker said at the WEF that "the UN, which is there to help bring peace will have to step up".
"Do I feel they have done enough? No, because we haven't gotten to that place."
Gilbert Houngbo, the new head of the UN's International Fund for Agricultural Development, said that efforts were needed to prepare South Sudan's agriculture for when peace returns.
"I visited places where people are trapped in what are called 'protection of civilian' camps. The women there face a choice between hunger or stepping out and being raped while looking for food," Oxfam International's Winnie Byanyima said
"Our guys are already active in preparing for an early recovery," Houngbo told AFP. "It's going to be difficult, but it's not impossible."
The theme of the 27th WEF on Africa is "Leadership in an era of disruption". It has drawn more than 1,200 participants, including several heads of state.
Oxfam released a report to coincide with the start of the forum which winds up on Friday, revealing that seven of the world's top 20 unequal countries are in Africa.
It warned that if economic growth continues to benefit only a small African elite, an additional 350 million people could be forced into poverty by 2032.
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